Gc ms analysis and antimicrobial activity of ethanolic. Systematic screening of them may result in the discovery of novel active compounds. This study aimed to investigate the chemical composition of ethyl acetate extract of c. Phytochemical and pharmacological studies of the whole. Calotropis procera essential oil contents and constituents were changed with different plant organs. Table 1 presents the chemical composition of the calotropis procera, gymnema sylvestre and hemidesmus indicus. Both the species are found throughout the world, but the calotropis. Secondary metabolites of calotropis have well known pharmaceutical and therapeutic applications. Calotropis gigantea is an important indian medicinal plant and widely used in ayurveda for. Calotropis procera contained many biological active chemical groups including, cardenolides, steroids, tannins, glycosides, phenols, terpenoids, sugars. Chemical compositions of leaf and stem essential oils of.
Diameter of inhibition zone on the growth of different bacterial species due to application of different concentration of water extract of. An unusual c18 isoursane pentacyclic triterpene isolated from the root bark of calotropis procera is assigned structure 1 on the basis of spectral and chemical studies. Chemical structures of phytoconstituents present in c. The chemical study of calotropis vishwa nath verma department of chemistry, faculty of natural sciences, university of guyana, turkeyen campus, georgetown, guyana, south america email address. It is widely used in the indian traditional medicinal system as well as in arabic, unani, and sudanese systems. Both of these species contain similar phytochemical. It has a deep taproot, 34 m deep, and a secondary root system with woody lateral roots that may rapidly regenerate adventitious shoots when the plant is injured. Phytochemical investigation of different plant parts of calotropis procera a. Calotropis procera, a small shrub is of immense pharmacological importance as a traditional medicine in the middle east, africa and south east asia figure 1. A study on calotropis procera leaf samples extracted the airdried leaf powder with different solvents such as petroleumether 6080c, benzene, chloroform, ethanol, and sterile water. Abhilasha mittal a and mohd alib aapex institute of pharmaceutical sciences, v. The root and latex of calotropis gigantea were screened for its antimicrobial and phytochemical activities. Asclepiadaceae has been known to the traditional systems of medicine and plant known as madar in unani medicinal system. Phytochemical investigation on stem of calotropis procera.
Chemical compounds in plants mediate their effects on the. Chemical constituents and pharmacological properties of. Chemical composition class of compound source reference. Terpenoid glycosides from the roots of calotropis procera.
Giganteol which was first obtained from the stem bark is one of them and a new triterpene alcohol, isogiganteol is the other. Phytochemical properties of leaf of calotropis procera obtained from methanol and petroleum. Calotropis procera, asclepiadaceae, roots, procerursenyl acetate, proceranol calotropis procera r. Calotropis procera is a plant which is used in several traditional medicine and folklore systems to cure various ailments as reported in the hindu literature.
Given the potent bioactivity of calotropin, calotropis gigantea has been used as a folk medicine in india for many years, and has been reported to have a variety of uses. Calotropis procera is among the species of medicinal plants that have traditionally been used for the treatment of parasites in small ruminants, stimulating the scientific validation of anthelmintic effects. Here, the calotropis procera latex fractions were investigated in an attempt to trace its phytochemical profile and measure its antiinflammatory and toxicity activity. The plant calotropis procera is known by different names in different part of the world. Leaves of this plant were investigated for its morphological, microscopical and phytochemical constituents to check the authenticity of the plant. Phytochemical and antibacterial properties of calotropis. Pdf the constituents and pharmacological properties of. The filtrate was evaporated under reduced pressure to obtain a dark brown gunmy material 750 g, partitioned between nhexane, chloroform, acetone, ethyl acetate and nbutanol, yielding petrolether soluble 80 g, chloroform soluble 285 g, ethyl acetate soluble 112 g and nbutanol soluble. Terpenoid glycosides from the roots of calotropis procera ait. International research journal of pharmaceutical and applied. Abstract calotropis procera contained many biological active chemical groups.
Insights on the phytochemical profile cyclopeptides and. Phytochemical investigation on stem of calotropis procera ait. Rashmi sharma published on 20191126 download full article with reference data and citations. Phytochemical investigation of calotropis procera ait roots. They regulate the ion channel physiology as in the. Two common species of calotropis have been mentioned in literature by ancient writers, c. The leaves of calotropis procera are said to be valuable as an antidote for snake bite, sinus fistula, rheumatism, mumps, burn injuries, and body pain. Chemical constituents of calotropis gigantea request pdf. Calotropis procera is regarded as useful medicinal plant and used in folk medicine.
Phytochemical analysis, antibacterial and antioxidant. Phytochemistry and ethnopharmaceutics of calotropis procera. An overview of its phytochemistry and pharmacology shoaib quazi, kumkum mathur, sandeep arora pharmacy wing, lachoo memorial college of science and technology, shastri nagar, jodhpur, rajasthan. Edeogai okwu and mbaebie studied a few chemical constituents 5. Comparative study on essential oil composition in various. Sep 27, 2017 chemical constituents of calotropis gigantea. Phytochemistry and ethnopharmaceutics of calotropis procera oloumi h 3 extensively branched root system and thick leaves with waxy coverage are the xerophytic adaptations. The present study was carried out to evaluate the antioxidant and antibacterial activity of leaves extracts of calotropis procera and calotropis gigantea and characterization of their bioactive metabolites by fourier transform infrared ftir spectroscopy and gas chromatographymass spectroscopy gcms. Antibacterial and phytochemical studies on calotropis gigantia. Calotropis procera and also examined the synergistic interaction between c. Often, its another variety calotropois procera is also used in the same name.
In ayurveda, indian practitioners have used the root and leaf of c. Characterization of chemical constituents of calotropis procera. Calotropis gigantea arka uses, dose, side effects, ayurveda. Antimicrobial activity and phytochemical analysis of. It is widely used in many ayurvedic treatments, both externally ksharasutra and internally. Hence, it is distributed in tropical and subtropical. The green fruits contain a toxic milky sap that is extremely bitter and turns into a gluey coating which is resistant to soap. Effect of latex extracts from euphorbia caducifolia and calotropis procera on rootknot nematode meloidogyne incognita infesting tomato and egg plant.
Widely it is used medicinally, to treat boils, infected wounds and other skin problems in people. Br asclepidiaceae, commonly known as swallow wart or milk weed, is a glabrous or hairy laticiferous shrub or small tree, found in tropical and subtropical asia and africa 15. This manuscript describes the gcms analysis and antimicrobial activity of an ethanolic extract of the leaves of the c. Biological morphology and ethanopharmocological importance. Phytochemical investigation of calotropis procera sciencedirect.
Ethnomedicine, phytochemistry and pharmacology of calotropis procera and tribulus terrestris medicinal plants possess an important advantage in the treatment of many diseases all over the world, especially in the developing countries. Aiton is a spreading shrub or mediumsized tree reaching 2. When using any agricultural chemicals please ensure that you always follow instructions on the label and any permit. International research journal of pharmaceutical and. Maoyuan wang 1, qing yang 1, xiaoxia yan 1, qinglong wang 1. Therefore, there is a chance for the presence of similar chemical constituents kalita and saikia, 2004. Phytochemical and pharmacological studies of the whole plant. Cardenolides, the principal steroidal toxins isolated from c. Chemical composition of calotropis procera essential oil is reported for the first time in literature. Phytochemical investigation of different plant parts of. Shrivastava, suchita singh, sanchita singh department of botany and biotechnology govt.
Calotropis procera is a medicinal plant whose pharmacological properties are associated with its latex. Calotropis gigantea called swetarka and calotropis procera called raktarka. The constituents and pharmacological properties of calotropis procera. Plants are richest source of bioactive organic chemicals on earth. Calotropis procera are widely used traditional medicinal plant to treat various ailments. Phytochemistry and ethnopharmaceutics of calotropis procera hakimeh oloumi1. They regulate the ion channel physiology as in the myocardium. Chemical analysis of leaf extracts of calotropis procera. Mudarol, the chief resinol component of the root bark ofcalotropis gigantea, has been separated into two isomeric compounds by fractional crystallisation of the acetates and also by chromatographic adsorption analysis of the free alcohols. Extraction and phytochemical investigation of calotropis procera.
This study aimed to investigate the chemical composition of ethyl acetate extract of calotropis procera latex eaecpl, assess the in vitro effect against haemonchus contortus and the. The chemical constituents could directly affect the cell membrane probably through receptors coupling to g proteins. Calotropis procera contained many biological active chemical groups including, cardenolides, steroids, tannins, glycosides, phenols, terpenoids, sugars, flavonoids, alkaloids and saponins. Calotropis gigantea and calotropis procera are to a great. Pharmacognostic standardization of leaves of calotropis. The phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and cardiac glycosides with a very high content in water extracts. Alkaloids, saponins, tannins and flavanoids were the main constituents present in leaf extract of plant and exhibited significant antimicrobial activity 15. Preliminary phytochemical screening and gc ms issn. Calotropis procera is also reported widely in various folklore preperations and ethnomedicines. Phytochemical and antibacterial activities of water, methanol and ethanol extracts obtained from the fruit and bark of calotropis procera were investigated in an attempt to evaluate its medicinal potentials. Phytochemical investigation of flavanoid of calotropis procera in.
This shrub is known to possess wide range of pharmacological activity. The aim of our study was to investigate chemical constituents of calotropis procera since no phytochemical investigation had been done previously in iraq, the. The pungent latex extracted from the leaves and flowers of calotropis procera is processed and used in the commercial preparation of eye tonics. Volatile oils from leaf and stem of calotropis procera ait, an asclepiadeae were analyzed for their constituents by means of gas chromatography and gas. Road, mansarowar, jaipur, india bdepartment of pharmacognosy and phytochemistry, faculty of pharmacy, jamia hamdard hamdard university, hamdard nagar, new delhi, india abstract. The effect of calotropis procera against fusarium solani agrees with the work of freitas et al. Request pdf on mar 1, 2012, arun kakkar and others published characterization of chemical constituents of calotropis procera find, read and cite all the.
Preliminary phytochemical analysis was done long with measurement of the leaf constants. It is a very common herb seen widely throughout india. Users of agricultural chemical products must always strictly comply with the directions on the label and the conditions of any permit. Antibacterial and phytochemical studies on calotropis gigantia l. Chemical composition of calotropis gigantea springerlink. Plant is a useful bioindicator to monitor pollution in varying concentrations of br. Chemical compositions of leaf and stem essential oils of calotropis. Calotropis procera is small, erect shrub, which is used in several herbal and empirical medicines to cure simple and deadly diseases and disorders. Chemical constituents the preliminary phytochemical screening of leaf.
The antimicrobial activity of the leaf extracts of calotropis procera. Chemical composition and in vitro activity of calotropis. The chemical study of calotropis vishwa nath verma department of chemistry, faculty of natural sciences, university of guyana. Calotropis gigantea linn commonly known as mudar or yercum belongs to the family asclepiadaceae. Calotropis procera, asclepiadeae, essential oil, hydro distillation, gc and gcms. Calotropis procera is a species of flowering plant in the family apocynaceae that is native to north africa, tropical africa, western asia, south asia, and indochina. Ethnomedicine, phytochemistry and pharmacology of calotropis. Extraction and phytochemical investigation of calotropis. Calotropis procera, belonging to the asclepidaceae family, is present more or less throughout india and in other warm, dry places such as, warizistan, afghanistan, egypt, and tropical africa. Chemical constituents of plants such as alkoloids, steroid, terpenoids, resin. Calotropis gigantea crown flower is a species of calotropis the giant milkweed, calotropis procera, is native to the old world from the arabian peninsula to west, north and east africa, also from southern asia to malaysia. In ancient ayurvedic medicine the plant calotropis procera linn. Chemical constituents of calotropis gigantea springerlink.
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